"Researchers at Northwestern University in Chicago have identified a breakdown in the protein-processing system of nerve cells in the brain and spinal cord of people with the neurodegenerative disease, according to a study published this week in the journal Nature. These neurons are unable to remove or repair damaged proteins. The damaged proteins then accumulate, impairing the ability of the cells to repair or maintain themselves.
"“This is the first time we have some evidence about a neurodegenerative condition where we have an idea about mechanism. When you have some idea about mechanism of disease, then you can start to straighten that pathway out and find drugs that would affect or normalize that pathway,” lead author Teepu Siddique, a professor of neurology, said in an interview."
Full article: Scientists discover new cause for ALS.
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